美洲原住民研究機構(The Institute of American Indian Studies，IAIS)包含了現代美洲印第安社群的研究和部落政治政策發展。機構也發展、協調和捐助各學科間的研究計畫，像是部落和部落大學、部落關聯和文化、議題發表、給予原住民教育和學生經濟資源，和主持美洲原住民議題的演講和會議。
1955年由州立大學董事會成立，1974年由南達科塔州議會認同，美洲原住民研究機構鼓勵了現代美洲原住民生活的研究，加強北部平原區的部落社區和大學間的交流，也支持美洲印第安研究系所和美洲原住民學生行政部門在大學裡成立。

The Institute of American Indian Studies conducts research and policy development on tribal governance and issues in contemporary American Indian society. The Institute also develops, coordinates and funds interdisciplinary research projects, sustains relations with tribes and tribal colleges, advises on tribal relations and culture, issues publications, administers several endowments supportive of Native American education and student life, and hosts numerous lectures and conferences on topical Native American questions.
Established in 1955 by the Board of Regents and subsequently recognized by the South Dakota Legislature in 1974, the work of the Institute of American Indian Studies encourages focused research on contemporary American Indian life, strengthening relations with tribal communities and colleges in the northern plains region, and supports the Department of American Indian Studies and Native American Student Services on campus.