*中心館藏網址:http://tulips.ntu.edu.tw/record=b2180856*cht

[ 摘要 ]
我們為了解台灣原住民痛風患者之臨床特性的差異，故選取三民鄉的布農族、尖石鄉的泰雅族以及阿里山鄉的鄒族等三地之痛風患者為研究族群。在族別的認定上，以父母親及祖父母皆為同一族別之個案才納入本研究。我們以家戶訪視的方式進行人口學資料、血液及24小時尿液的收集，於民國87年10月至民國88年4月間共收得168個個案，布農族有52人、泰雅族有64人及鄒族有52人，但其中有尿液資料者布農族35人、泰雅族43人及鄒族44人共122人。
研究結果發現女性患者的平均發病年齡較晚，有合併症的情形也較嚴重，而且其腎功能也比男性患者略差。男性痛風患者的血清尿酸值比女性痛風患者高。泰雅族的平均發病年齡為38.6歲是三族中發病年齡最早的。另外，鄒族之痛風患者之腎功能比非鄒族之患者差，而且病程愈長者其腎功能愈差。病程愈長愈容易產生痛風石的。有痛風石的個案之腎功能比沒有痛風石的患者差。30歲以前發病之痛風患者68﹪有痛風家族史。
有人認為女性痛風大多屬於繼發性，所以有合併症的情形較多，但因本研究無法確認這些疾病的時序性，故無能作進一步的探討。在族別的比較上發現，泰雅族痛風患者的平均發病年齡比較早，可能是氣候所造成的。年輕的痛風患者可能因有家族聚集的情形而導致較早發病。
本研究限於非痛風患者之24小時尿液採集困難，因此無法比較痛風與非痛風患者之腎功能。再者，因非原住民之痛風盛行率很低，所以在一社區中非原住民之痛風個案較少見而難以收集，故在此亦無法比較非原住民痛風患者與原住民痛風患者之臨床特性的差異。

[ 英文摘要 ]
A community-based survey to study the clinical features and renal function in Taiwan aborigines gouty patients. A total of 168 cases were included in the study, and there were 52 Bunun gouty patients, 64 Atayal gouty patients and 52 Tsou gouty patients.
We found that Women developed gout significantly later compared with men, more frequently had associated diseases. The renal function was more aggravated in female with gout than in male with gout. Male patients with gout had a higher mean serum urate concentration than did female patients with gout. The mean estimated onset of gout was significantly earlier in Atayal patients than in other tribs’ patients. The renal function was impaired in patients that the estimated duration of gout was longer. The renal function was significantly more aggravated in Tsou with gout than others with gout. The clinically visible tophi was easily developed in patients that the estimated duration of gout was longer. A further significant decline of the renal function was noted in gouty patients with clinically visible tophi .68 percent of the patients with onset of gout under 30 years old have a positive family history.
Someone though that female with gout was the second gout, so more frequently had associated diseases. But this study didn’t identify that the temporality of these diseases , we didn’t determine the theory. The racial differences in the estimated onset of gout maybe resulted from climatic factors. We can’t compare the renal function in both the gouty patients and normal individuals, because 24-hour urine of normal individuals is different collected. Because the prevalence of gout among non-aborigines was low, non-aborigines with gout is rare in a community, there isn''t compare the difference with the clinical features of gout between the aborigines with non-aborigines.