依類型 族群 主題   
 
 
2007.06.01 ~ 2008.06.01
幽門螺旋桿菌感染與體內氧化壓力之相關研究 The association between H. pylori infection and oxidative stress
族群: 跨族群  
主題: 學術研究、醫療保健  
作者 劉子涵
學校系所 臺北醫學大學公共衛生學研究所
地點 花蓮縣 全部    
研究內容

[ 摘要 ]

全球約有50%以上的人感染幽門螺旋桿菌(H. pylori; HP),感染HP與消化道疾病的發生有密切相關,在1994年世界衛生組織亦將HP歸類為第一級致癌物。當感染HP引起胃部的發炎反應,會使體內氧化壓力增加。因此,本研究係探討HP感染的盛行率、危險因子,以及HP感染與體內氧化壓力指標間之相關性。

本研究採橫斷性研究,從花蓮門諾醫院共收集116位接受胃腸道內視鏡檢查之病人進入研究。收集個案之問卷、HP感染檢驗結果,以及血液檢體以進行脂質過氧化物質(MDA)、抗氧化能力(GSH、SOD)、微量金屬元素(Zn、Cu)分析。

本研究中HP感染者有45位 (38.8%),平均年齡為46.8歲;女性佔65.5% (76/116),非原住民佔78.5% (91/116)。在盛行率方面,原住民族群的HP盛行率顯著性高於非原住民族群(原住民=60.0%,非原住民= 33.0%;OR=3.05,95% CI=1.23-7.59),此外,原住民與非原住民在年齡、BMI值、喝酒習慣,以及教育程度方面,皆有達統計上顯著差異(p<0.05)。校正可能的干擾因子後,MDA濃度與HP感染呈顯著性相關(p=0.048)。

原住民族群與HP感染有密切的相關,而HP感染可能會影響血漿中MDA濃度,造成體內氧化壓力增加。

[ 英文摘要 ]

Helicobacter pylori (H. pylori; HP) chronically infect the stomach of more than half of the human population in the world and it has been implicated in the pathogenesis of a number of digestive tract disorders. In 1994, HP was classified as a class I carcinogenic agent. HP infection induces an inflammatory response that result oxidative burst. The aim of this study is to investigate the prevalence and risk factors of HP infection. Additionally, also investigate the relationship between oxidative stress and HP infection.

This study is performed by cross-sectional study. A total of 116 patients with digestive tract disorder underwent endoscopy in Mennonite Christian Hospital in Hula lien were enrolled. Questionnaires, laboratory tests for HP, and blood samples are collected. The lipid peroxidation (MDA), antioxidative status (GSH, SOD), and trace element (Zn, Cu) in the blood were determined.

Among 116 subjects, there 45 (38.8%) were HP-infected. The averageage was 46.8 years old. Of all patients, 65.5% were female (76/116) and 78.5% were non-aborigine (91/116). The prevalence of HP in aborigine was significant higher than non-aborigine (60.0% vs. 33.0%; OR=3.05,95% CI=1.23-7.59). Furthermore, aborigine and non-aborigine were significant different in age, BMI, drinking, and education (p<0.05). After adjusted possible confounding factors, the MDA concentrations was significant related with HP infection (p=0.048).

In this study, we find that the aborigine and HP infection were highly correlation, and HP infection affected the MDA concentrations in the plasma.